Awakawa, T.; Mori, T.; Nakashima, Y.; Zhai, R.; Wong, C.P.; Hillwig, M.L.; Liu, X.; Abe, I. Molecular Insight into the Mg2+ -Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1. Angewandte Chemie International Edition 2018, 57 (23), 6810-6813.
Xu, M.; Hillwig, M.L.; Tiernan, M.S.; Peters, R.J. 鈥淧robing labdane-related diterpenoid biosynthesis in the fungal genus Aspergillus.鈥� Journal of Natural Products 2017, 80 (2), 328-33.
Mitchell, A. J.; Zhu, Q.; Maggiolo, A. O.; Ananth, N. R.; Hillwig, M. L.; Liu, X.; Boal, A. K. 鈥淪tructural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.鈥� Nature Chemical Biology 2016, 12 (8), 636-40.
Hillwig, M. L.; Zhu, Q.; Ittiamornkul, K.; Liu, X. 鈥淒iscovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules.鈥� Angewandte Chemie International Edition 2016, 55 (19), 5780-4.
Mafu, S.; Jia, M.; Zi, J.; Morrone, D.; Wu, Y.; Xu, M.; Hillwig, M. L.; Peters, R. J. 鈥淧robing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis.鈥� Proceedings of the National Academy of Sciences of the U.S.A. 2016, 113 (9), 2526-2531.
Zhu, Q.; Hillwig, M. L.; Doi, Y.; Liu, X. 鈥淎liphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity.鈥� Chembiochem 2016, 17 (6), 466-70.
Liu, X.; Hillwig, M. L.; Koharudin, L. M. I.; Gronenborn, A. M. 鈥淯nified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase.鈥� Chemical Communications 2016, 52 (8), 1737-1740.
Ittiamornkul, K.; Zhu, Q.; Gkotsi, D. S.; Smith, D. R. M.; Hillwig, M. L.; Nightingale, N.; Goss, R. J. M.; Liu, X. 鈥淧romiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids.鈥� Chemical Science 2015, 6 (12), 6836-6840.
Medema, M.H.; Kottmann, R; Yilmaz, P.; Cummings, M.; Biggins, J.B.; Blin, K.; de Bruijn I.; Chooi, Y.H.; Claesen, J.; Coates, R.C.; Cruz-Morales, P.; Duddela, S.; D眉sterhus, S.; Edwards, D.J.; Fewer, D.P.; Garg, N.; Geiger, C.; Gomez-Escribano J.P.; Greule, A.; Hadjithomas, M.; Haines, A.S.; Helfrich, E.J.; Hillwig, M.L.; Ishida, K.; Jones, A.C.; et al. 鈥淢inimum Information about a Biosynthetic Gene cluster.鈥� Nature Chemical Biology 2015, 11 (9), 625-31.
Hillwig, M.L. & Liu, X. 鈥淎 new family of iron-dependent halogenases acts on freestanding substrates.鈥� Nature Chemical Biology 2014, 10 (11), 921-3.
Xu, M.; Hillwig, M.L.; Lane, A.L.; Tiernan, M.S.; Moore, B.S.; Peters, R.J. 鈥淐haracterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola.鈥� Journal of Natural Products 2014 77 (9), 2144-7.
Hillwig, M.L.; Fuhrman, H.A.; Ittiamornkul K.; et al. 鈥淚dentification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in Stigonematalean Cyanobacterium Hapalosiphon welwitschii.鈥� Chembiochem 2014, 15 (5), 665-9.
Gao, W.; Sun, H.-X.; Xiao, H.; Cui, G.; Hillwig, M. L.; et al. 鈥淐ombining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza.鈥� BMC Genomics 2014, 28, 15:73.
Hillwig, M.L.; Zhu, Q; Liu, X. 鈥淏iosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua.鈥� ACS Chemical Biology 2014, 9 (2), 372-7.
16. Guo, J.; Zhou, Y.J., Hillwig, M.L.; et al. 鈥淐YP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.鈥� Proceedings of the National Academy of Sciences of the U.S.A. 2013, 110 (29), 12108-13.
Wu, Y.; Wang, Q.; Hillwig, M. L.; Peters, R. J. Picking sides: Distinct roles for CYP76M6 and -8 in rice oryzalexin biosynthesis. Biochemical Journal 2013, 454 (2), 209-16.
Wang, Q.; Hillwig, M.L.; Wu, Y.; et al. CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism. Plant Physiology 2012, 158 (3), 1418-25.
Wang, Q.; Hillwig, M.L.; Okada, K.; et al. 鈥淐haracterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster.鈥� Journal of Biological Chemistry 2012, 287 (9), 6159-68.
Hillwig, M.L.; Xu, M.; Toyomasu, T.; et al. 鈥淒omain loss has independently occurred multiple times in plant terpene synthase evolution.鈥� The Plant Journal. 2011, 68 (6), 1051-60.
Mafu, S.; Hillwig, M. L.; Peters, R. J. 鈥淎 Novel Labda-7,13E-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.鈥� ChemBioChem 2011, 12(13):1984-7.
Wu, Y.; Hillwig, M.L.; Wang, Q.; Peters, R.J. "Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7.鈥� FEBS Letters 2011, 585 (21), 3446-51.
Morrone, D.; Hillwig, M.L.; Mead, M.E.; Lowry, L.; Fulton, B.F.; Peters, R.J. 鈥淓vident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals.鈥� Biochemical Journal 2011, 435 (3), 589-95.
Hillwig, M.L.; Mann F.M.; Peters, R.J. 鈥淒iterpenoid biopolymers: new directions for renewable materials engineering.鈥� 2011, 95 (2), 71-6.
Wang, Q., Hillwig, M.L.; Peters, R.J. "CYP99A3: Functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice." The Plant Journal 2011, 65(1), 87-95.
Maugel N.; Mann F.M.; Hillwig M.L.; Peters R.J.; Snider, B.B. 鈥淪ynthesis of (卤)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene).鈥� Organic Letters 2009, 2010, 12 (11), 2626-9.
Gao, W., Hillwig M.L., Huang L., Cui G., Wang X., Kong J., Yang B., Peters R.J. "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights." Organic Letters 2009, 11 (22), 5170-3.
Birt D.F., Widrlechner M.P., Hammer K.D., Hillwig M.L., Wei J., Kraus G.A., Murphy P.A., et al. 鈥淗ypericum in infection: Identification of anti-viral and anti-inflammatory constituents.鈥� Pharmaceutical Biology 2009, 47 (8), 774-782.
Hillwig, M.L.; Hammer, K.D.P.; Birt, D.F.; Wurtele, E.S. 鈥淐haracterizing the Novel Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides.鈥� Journal of Agricultural and Food Chemistry 2008, 56 (12), 4359-66.
Hammer, K.D.P.; Hillwig, M.L.; Wurtele, E.S.; Birt, D.F. Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4-component system mimicking an Hypericum perforatum fraction. Phytochemistry 2008, 69, 2354-2362.
Hammer, K.D.P.; Hillwig, M.L.; Wurtele, E.S.; Birt, D.F. 鈥淚nhibition of prostaglandin E2 production by anti-inflammatory Hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells.鈥� Journal of Agricultural and Food Chemistry 2007, 55 (18), 7323-31.
Xu, M.; Hillwig, M.L.; Prisic, S.; Coates, R.M.; Peters, R.J. 鈥淔unctional identi?cation of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products.鈥� The Plant Journal 2004, 39 (3), 309-18.
Achievements
National Institutes of Health (NIH) Ruth L. Kirschstein National Research Service Award (NRSA) Individual Trainee Fellowship (F22) from 2004 to 2008.